ABSTRACT
This study was conducted to evaluate the role of Unani herbal drugs Pepsil and Safoof-e-katira on the gastro esophageal reflux disease [GERD]. This was multicentre r and omized case control study conducted at Matab Hakeem Muhammad Noor-ud-din, Burewala; Aziz Muhammad din Medical and Surgical Centre, BurewalaandShifa-ul-mulk Memorial Hospital, Hamdard University Karachi. The patients were selected according to inclusion and exclusion criteria. In test group-1 the male female ratio was 40%, 60%; test group-2 was 42%, 58% and in control group was 44%, 56% respectively. The observed symptoms in the study were increased appetite [TG-1-95%, TG-2-95% and CG-89%], difficulty in swallowing [TG-1-93%, TG-2-96% and TC-94%], belching/burping [TG-1-97%, TG-2-97% and CG-95%], vomiting [TG-1-90%, TG-2-96% and CG-89%], heart burn [TG-1-100%, TG-2-100% and CG-98%], palpitation [TG-1-100%, TG-2-100% and CG-97%], epigastric pain [TG-1-97%, TG-2-97% and CG-90%], abdominal cramps [TG-1-97%, TG-2-98% and CG-95%], tenesmus [TG-1-100%, TG-2-100% and CG-97%], flatulence [TG-1-100%, TG-2-75% and CG-95%], wakeup during sleep [TG-1-94%, TG-2-87% and CG-94%]. The p-value of the results of the symptoms was 0.000 except flatulence where the value was 0.001. The statistical results of the study prescribed that all the drugs studied [Pepsil, Safoof-e-katiraandOmeprazole] are highly significant. The herbal coded drug Pepsil showed no side effects and unani herbal drug safoof-e-katira showed minimum result of 75% in the patients while Omeprazole resulted with some side effects. In the result it can be concluded that the herbal coded drug Pepsil is a potent herbal drug for gastro esophageal reflux disease.